Positive association between dietary exposure to polybrominated diphenyl ethers and breast cancer risk in the French E3N cohort: the role of vegetable oil consumption

Background and aim Exposure to endocrine-disrupting chemicals, like Polybrominated diphenyl ethers (PBDE), is suspected play a role in the occurrence of breast cancer. Moreover, there growing evidence that food chemical contaminants could interact with different components diet, especially lipophilic ones, such as PBDE. In an in-vitro study, vegetable oil has been shown increase bioaccessibility The objective present study was assess association between dietary intake PBDE cancer risk French E3N cohort investigate potential modification this by consumption or lipid intake. Methods included 67 879 women. Intake individual were estimated using data from validated semi-quantitative frequency questionnaire. Hazard Ratios (HR) 95% Confidence Intervals (CI) for total risk. Interaction measures on both additive multiplicative scales. Results women followed maximum 21.4 years, 5 686 developed incident A positive linear trend highlighted quintile groups risk, borderline statistical significance (p-trend=0.06, HRQ5vsQ1 95%CI: 1.09 [0.99;1.20]). significant Higher effect sizes high consumers oil, i.e. ≥4.6 g/day (HRQ5vsQ1 1.23 [1.08; 1.40]), almost no found low 0.97 [0.86; 1.10]). Conclusions Highlighting interactions nutrients chemicals crucial develop efficient recommendations limit negative health effects associated exposure contaminants. Keywords ethers; Breast cancer; Endocrine-disrupting chemicals;